Rosalie Bradford holds the Guinness World Record for most weight lost by a woman, some 900lbs+. Always heavy, she weighed over 300lbs at age 15. Reports vary, but her highest weight is listed at over 1,100 pounds [some list her at over 1,200]
Eventually she became so depressed and frustrated that she attempted to commit suicide with painkillers, which apparently she was too fat to do: reports say her large amount of bodyfat absorbed the potentially lethal dose and only caused her to sleep for two days.
She started her weight loss with help from Richard Simmons [who on a side note annoys me tremendously] and her ‘exercise’ was clapping her hands to music as “it was all she could do”. She lost 400lbs in her first year, and eventually lost a total of over 900lbs.
In a stroke of irony – she died in 2006 from complications from her obesity… after losing 900lbs